Creative Biogene is a leading service provider in mRNA-based drug research and development (RD). Our scientists have extensive experience in developing mRNA delivery systems and are dedicated to offering a range of optimal mRNA delivery vehicles that cater to specific applications. These include lipid-based delivery systems, polymer-based delivery systems, polypeptide-based delivery systems, and hybrid delivery systems. Our services encompass customized design, flexible production, and meticulous optimization of mRNA delivery systems, aimed at helping customers achieve scalability and clinical utility.
The Necessity of Developing Delivery Systems
With numerous advantages, in vitro transcribed (IVT) mRNA technology is a promising tool for the development of novel therapeutics. Its applications range from vaccinations and protein replacement therapies to gene editing. However, mRNA-based therapies face several obstacles, including large molecular size, intrinsic instability, and challenges in cell targeting, as well as high susceptibility to enzymatic degradation. These factors result in low uptake and potency for naked mRNA, highlighting the urgent need for efficient mRNA delivery systems. Among the various developed systems, lipid-based vehicles are the most commonly used for IVT mRNA delivery, while polymer-based systems are recognized for their safety profile, flexible modification, and cost-effectiveness.
To create effective delivery systems for IVT-mRNA, several key criteria must be followed:
- Reduce nonspecific uptake
- Enhance tissue permeation
- Ensure targeted intracellular delivery
- Control release kinetics
Developing mRNA Delivery Systems at Creative Biogene
An effective carrier for mRNA-based therapy not only protects mRNA but also ensures efficient intracellular translation while preventing immune activation. Drawing on our expertise in material sciences, nanotechnology, and nucleic acid chemistry, we are developing new mRNA delivery systems specifically tailored to the unique requirements of our clients.
Our Specific Services Include:
Lipid-based mRNA Delivery System: The most widely used non-viral carrier for IVT mRNA delivery. We leverage deep knowledge in targeted delivery to identify novel compounds and optimize formulations.
Polymer-based mRNA Delivery System: A promising family of carriers offering a good safety profile and flexible modification options, allowing us to evaluate the effects of different synthetic parameters on mRNA delivery performance.
Peptide-based mRNA Delivery System: Recently attracting attention, these systems benefit from biocompatibility and biodegradability. We offer custom polypeptide-based carrier design, synthesis, and production services.
Hybrid mRNA Delivery System: As single-functional systems cannot meet growing application needs, hybrid delivery carriers with multifunctionality and flexibility are being developed.
